Publications
2025
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Garbarino VR, Palavicini JP, Melendez J, Barthelemy NR, He Y, Kautz TF, Lopez-Cruzan M, Mathews JJ, Xu P, Zhang B, Saliba A, Ragi N, Sharma K, Mason D, Johnson S, Hendrix S, Craft S, Petersen RC, Espindola-Netto JM, Xue A, Tchkonia T, Kirkland JL, Salardini A, Musi N, Bateman RJ, Gonzales MM, Orr ME. Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer's disease. Neurotherapeutics. 2025 Apr 23:e00591. doi: 10.1016/j.neurot.2025.e00591. Online ahead of print.
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Frost B, Rowe JB, Akinyemi RO, Abisambra JF, Ashton NJ, Brendel M, Buée L, Butler D, Carrillo MC, Chung P, Clelland CD, DeVos SL, Diaz K, Edelmayer RM, Elahi FM, Ellajosyula R, Ewen C, Fontana IC, Galas MC, Hansson O, Höglinger G, Horie K, Ibanez A, Jacobs L, Maina MB, Malpetti M, McDade E, McEwan W, Montoliu-Gaya L, Mummery CJ, Orr ME, Rohrer JD, Rommel A, Sastre C, Spires-Jones TL, Tee BL, Viney TJ, Walker JM, Wegmann S, Wildsmith K, Yadav R, Mahinrad S, Sexton C. Proceedings of the Tau2024 Global Conference. Alzheimers Dement. 2025 May;21(5):e70078. doi: 10.1002/alz.70078.
2024
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Melendez J, Sung YJ, Orr ME, Yoo A, Schinder S, Cruchaga C, Bateman RJ. An Interpretable Machine Learning-Based Cerebrospinal Fluid Proteomics Clock for Predicting Biological Age Reveals Novel Insights into Brain Aging. Aging Cell. 2024 Jun 24:e14230. doi: 10.1111/acel.14230. Online ahead of print.
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Damuka N, Orr ME, Irmen RE, Krizan I, Miller M, Gollapelli KK, Boopal B, Deep O, Bansode A, Lockhart SN, Jadiya P, Bashetti N, Kuman JV, Mintz, A, Lee J, Macauley SL, Whitlow C, Mintz A, Craft S, Sai K Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [11C]MPC-6827 PET imaging in rodent models of Alzheimer’s-related pathology. Alzheimer’s Dement. 2024;1-12.
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Riessland M, Ximerakis M, Jarjour AA, Zhang B, Orr ME. Therapeutic targeting of senescent cells in the CNS. Nat Rev Drug Discov. 2024 Sep 30. doi: 10.1038/s41573-024-01033-z.
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Hudson HR, Riessland M, Orr ME. Defining and characterizing neuronal senescence, ‘neurescence’ as GX arrested cells. Trends Neurosci. 2024 Oct 9:S0166-2236(24)00178-4. doi: 10.1016/j.tins.2024.09.006.
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Frost B, Rowe JB, Akinyemi RO, Abisambra JF, Ashton NJ, Brendel M, Buée L, Butler D, Carrillo MC, Chung P, Clelland CD, DeVos SL, Diaz K, Edelmayer RM, Elahi FM, Ellajosyula R, Ewen C, Fontana IC, Galas MC, Hansson O, Höglinger G, Horie K, Ibanez A, Jacobs L, Maina MB, Malpetti M, McDade E, McEwan W, Montoliu-Gaya L, Mummery CJ, Orr ME, Rohrer JD, Rommel A, Sastre C, Spires-Jones TL, Tee BL, Viney TJ, Walker JM, Wegmann S, Wildsmith K, Yadav R, Mahinrad S, Sexton C. Proceedings of the Tau2024 Global Conference. Alzheimers Dement. 2025 May;21(5):e70078. doi: 10.1002/alz.70078.
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Gonzales MM, Garbarino VR, Kautz TF, Song X, Lopez-Cruzan M, Linehan L, Van Skike CE, De Erausquin GA, Galvan V, Orr ME, Musi N, He Y, Bateman RJ, Wang CP, Seshadri S, Kraig E, Kellogg D Jr. Rapamycin treatment for Alzheimer's disease and related dementias: a pilot phase 1 clinical trial. Commun Med (Lond). 2025 May 20;5(1):189. doi: 10.1038/s43856-025-00904-9.
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Dehkordi SK, Sajedi S, Heshmat A, Orr ME, Zare H. Identification of markers for neurescence through transcriptomic profiling of postmortem human brains. NPJ Aging. 2025 Jul 1;11(1):57. doi: 10.1038/s41514-025-00235-y.
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2023
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Walker JM, Orr ME, Orr TC, Thorn E, Christie T, Yokoda RT, Vij M, Ehrenberg AJ, Marx GA, McKenzie AT, Kauffman J, Selmanovic E, Wisniewski T, Drummond ES, White CL, Crary JF, Farrell K, Kautz T, Daoud EV, Richardson TE. Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer disease and primary age-related tauopathy. 2023. Alzheimers Dement. 2023 Sep 30. PMID: 37777848.
Bhoopal B, Gollapelli K, Damuka N, Miller M, Krizan I, Bansode A, Register T, Frye B, Kim J, Mintz A, Orr ME; Lockhart A, Whitlow C, Craft S, Shively C, Solingapuram Sai KK. Preliminary PET imaging of a microtubule-based PET radioligand, [11C]MPC-6827 in a nonhuman primate model of Alzheimer’s disease. ACS Chem Neurosci. 2023 Sep 19. PMID: 37724996
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Riessland M and Orr ME. Translating the Biology of Aging into New Therapeutics for Alzheimer’s Disease: Senolytics. J Prev Alzheimers Dis. 2023;10(4):633-646. doi: 10.14283/jpad.2023.104.
2022
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Walker JM, Kazempour Dehkordi S, Fracassi A, Vanschoiack A, Pavenko A, Taglialatela G, Woltjer R, Richardson TE, Zare H, Orr ME. Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling. Acta Neuropathol Commun. 2022 Feb 14; 10(1):23. PMID: 35164877.
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Xu P, Wang M, Song WM, Wang Q, Yuan GC, Sudmant PH, Zare H, Tu Z, Orr ME, Zhang B. The landscape of human tissue and cell type specific expression and co-regulation of senescence genes.
Mol Neurodegener. 2022 Jan 09; 17(1):5. PMID: 35000600.
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2021
Dehkordi SK, Walker J, Sah E, Bennett E, Atrian F, Frost B, Woost B, Bennett RE, Orr TC, Zhou Y, Andhey PS, Colonna M, Sudmant PH, Xu P, Wang M, Zhang B, Zare H, Orr ME. Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology. Nat Aging. 2021 Dec; 1(12):1107-1116. PMID: 35531351.
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Sah E, Krishnamurthy S, Ahmidouch MY, Gillispie GJ, Milligan C, Orr ME. The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration. Life (Basel). 2021 Mar 11; 11(3). PMID: 33799628.
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Gillispie GJ, Sah E, Krishnamurthy S, Ahmidouch MY, Zhang B, Orr ME. Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells-Implications for Cancer and Neurodegeneration. Life (Basel). 2021 Feb 17; 11(2). PMID: 33671362.
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2020 - Earlier
Orr ME, Reveles KR, Yeh CK, Young EH, Han X. Can oral health and oral-derived biospecimens predict progression of dementia? Oral Dis. 2020 Mar; 26(2):249-258. PMID: 31541581.
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Liang H, Nie J, Van Skike CE, Valentine JM, Orr ME. Mammalian Target of Rapamycin at the Crossroad Between Alzheimer's Disease and Diabetes. Adv Exp Med Biol. 2019; 1128:185-225. PMID: 31062331.
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Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME. Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell. 2018 12; 17(6):e12840. PMID: 30126037.
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Orr ME, Sullivan AC, Frost B. A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies. Trends Pharmacol Sci. 2017 07; 38(7):637-648. PMID: 28455089.
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Orr ME, Garbarino VR, Salinas A, Buffenstein R. Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain. Front Neurosci. 2016; 10:504. PMID: 27877105.
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Triplett JC, Swomley AM, Kirk J, Grimes KM, Lewis KN, Orr ME, Rodriguez KA, Cai J, Klein JB, Buffenstein R, Butterfield DA. Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat. Neurochem Res. 2016 Jul; 41(7):1625-34. PMID: 26935741.
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Triplett JC, Tramutola A, Swomley A, Kirk J, Grimes K, Lewis K, Orr M, Rodriguez K, Cai J, Klein JB, Perluigi M, Buffenstein R, Butterfield DA. Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity. Biochim Biophys Acta. 2015 Oct; 1852(10 Pt A):2213-24. PMID: 26248058.
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Triplett JC, Swomley A, Kirk J, Lewis K, Orr M, Rodriguez K, Cai J, Klein JB, Buffenstein R, Butterfield DA. Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: the naked mole-rat. J Neurochem. 2015 Aug; 134(3):538-50. PMID: 25940666.
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Garbarino VR, Orr ME, Rodriguez KA, Buffenstein R. Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates. Arch Biochem Biophys. 2015 Jun 15; 576:8-16. PMID: 25841340.
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Orr ME, Garbarino VR, Salinas A, Buffenstein R. Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent. Neurobiol Aging. 2015 Mar; 36(3):1496-504. PMID: 25576082.
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Orr ME, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging. 2014 Jun; 35(6):1233-42. PMID: 24411482.
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Medina DX, Orr ME, Oddo S. Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice. Neurobiol Aging. 2014 Jan; 35(1):79-87. PMID: 23954172.
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George L, Chaverra M, Wolfe L, Thorne J, Close-Davis M, Eibs A, Riojas V, Grindeland A, Orr M, Carlson GA, Lefcort F. Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18698-703. PMID: 24173031.
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Orr ME, Oddo S. Autophagic/lysosomal dysfunction in Alzheimer's disease. Alzheimers Res Ther. 2013; 5(5):53. PMID: 24171818.
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​Orr ME, Pitstick R, Canine B, Ashe KH, Carlson GA. Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau. PLoS One. 2012; 7(6):e39328. PMID: 22723997.
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Purevdorj-Gage B, Orr ME, Stoodley P, Sheehan KB, Hyman LE. The role of FLO11 in Saccharomyces cerevisiae biofilm development in a laboratory based flow-cell system. FEMS Yeast Res. 2007 May; 7(3):372-9. PMID: 17233763.